Determinants of outcome and safety of intravenous rt-PA therapy in the very old: a clinical registry study and systematic review.

improvement in the rehabilitation of the chronically ill. Md State Med J 1965; 14: 61–5. 10. Lawton MP, Brody EM. Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist 1969; 9: 179–86. 11. Lobo A, Saz P, Marcos G et al. Revalidación y normalización del Mini-Examen Cognoscitivo (primera versión en castellano del Mini-mental Status Examination) en la población general geriátrica. Med Clin (Barc) 1999; 112: 767–74. 12. Charlson ME, Pompei P, Ales KL et al. A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation. J Chronic Dis 1987; 40: 373–83. 13. Wilkinson TJ, Sainsbury R. The association between mortality, morbidity and age in New Zealand’s oldest old. Int J Aging Hum Dev 1998; 46: 333–43. 14. Formiga F, Chivite D, Manito N et al. One-year follow-up of heart failure patients after their first admission. Q J Med 2004; 97: 81–6. 15. Steward S, MacIntyre K, Hole DJ et al. More ‘‘malignant’’ than cancer? Five-year survival following a first admission for heart failure. Eur J Heart Fail 2001; 3: 315–22. 16. Perls TT, Morris JN, Ooi WL et al. The relationship between age, gender and cognitive performance in the very old: the effect of selective survival. J Am Geriatr Soc 1993; 41: 1193–201. 17. Andersen K, Nybo H, Gaist D et al. Cognitive impairment and mortality among nonagenarians: The Danish 1905 cohort survey. Dement Geriatr Cogn Disord 2002; 13: 156–63.